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Yoichiro Iwakura Selected Research

Arthritis (Polyarthritis)

11/2022mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome.
1/2021IL-1β-driven osteoclastogenic Tregs accelerate bone erosion in arthritis.
1/2021TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.
5/2017Megakaryocytes compensate for Kit insufficiency in murine arthritis.
9/2015CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis.
6/2015IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vγ6(+)γδ T cells.
4/2015IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.
1/2015Antibiotic-killed Staphylococcus aureus induces destructive arthritis in mice.
10/2014Contribution of mast cell-derived interleukin-1β to uric acid crystal-induced acute arthritis in mice.
2/2014Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-β-induced Foxp3 expression.
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Yoichiro Iwakura Research Topics

Disease

108Inflammation (Inflammations)
11/2023 - 02/2003
81Infections
05/2024 - 11/2001
41Arthritis (Polyarthritis)
11/2022 - 02/2002
38Neoplasms (Cancer)
12/2023 - 05/2002
24Colitis
01/2022 - 12/2002
23Rheumatoid Arthritis
09/2015 - 02/2002
16Autoimmune Diseases (Autoimmune Disease)
01/2021 - 02/2006
16Pneumonia (Pneumonitis)
01/2021 - 11/2001
11Dermatitis
03/2023 - 08/2010
11Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
08/2022 - 02/2006
11Contact Dermatitis (Eczema, Contact)
01/2019 - 02/2003
11Necrosis
11/2018 - 03/2002
11Hypersensitivity (Allergy)
01/2018 - 09/2002
10Carcinogenesis
12/2023 - 02/2007
10Psoriasis (Pustulosis Palmaris et Plantaris)
11/2021 - 08/2010
10Asthma (Bronchial Asthma)
01/2021 - 04/2003
9Neoplasm Metastasis (Metastasis)
12/2023 - 01/2002
9Mycoses (Diseases, Fungus)
11/2022 - 01/2007
9Obesity
01/2022 - 09/2003
8Wounds and Injuries (Trauma)
01/2021 - 02/2004
8Reperfusion Injury
01/2019 - 09/2006
8Hyperplasia
01/2018 - 12/2004
8Ischemia
10/2017 - 06/2002
8Atherosclerosis
10/2013 - 04/2003
7Disease Progression
11/2023 - 01/2007
7Virus Diseases (Viral Diseases)
01/2022 - 03/2002
7Experimental Arthritis
12/2021 - 12/2003
7Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2021 - 05/2006
7T-Cell Leukemia (Leukemia, T Cell)
03/2010 - 02/2002
6Sepsis (Septicemia)
04/2023 - 06/2005
5Fibrosis (Cirrhosis)
01/2021 - 12/2009
5Communicable Diseases (Infectious Diseases)
01/2019 - 06/2005
5Melanoma (Melanoma, Malignant)
01/2019 - 05/2002
5Infarction (Infarctions)
03/2017 - 03/2003
5Hepatitis
04/2014 - 07/2004
4Colorectal Neoplasms (Colorectal Cancer)
01/2023 - 02/2010
4Skin Diseases (Skin Disease)
05/2022 - 09/2011
4Porcine Reproductive and Respiratory Syndrome (PRRS)
01/2022 - 02/2011
4Chronic Obstructive Pulmonary Disease (COPD)
01/2021 - 11/2002
4Hypertension (High Blood Pressure)
01/2021 - 02/2010
4Lung Diseases (Lung Disease)
12/2020 - 09/2008
4Multiple Sclerosis
12/2018 - 07/2006
4Pain (Aches)
08/2018 - 02/2006
4Granuloma
04/2016 - 02/2007

Drug/Important Bio-Agent (IBA)

122Interleukin-17 (Interleukin 17)IBA
12/2023 - 09/2002
98CytokinesIBA
05/2024 - 11/2001
54Interleukin-1 (Interleukin 1)IBA
01/2019 - 02/2002
33Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
04/2023 - 06/2002
30InterleukinsIBA
01/2021 - 11/2001
29Interleukin-6 (Interleukin 6)IBA
04/2023 - 11/2001
29Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
01/2021 - 08/2002
22Proteins (Proteins, Gene)FDA Link
04/2023 - 02/2003
21Interleukin-23 (Interleukin 23)IBA
01/2018 - 04/2004
19Interferon-gamma (Interferon, gamma)IBA
12/2017 - 11/2001
17InflammasomesIBA
11/2023 - 08/2010
17AntigensIBA
08/2022 - 01/2002
17ChemokinesIBA
11/2021 - 09/2006
15dectin 1IBA
01/2023 - 01/2007
14Messenger RNA (mRNA)IBA
04/2023 - 10/2003
13LigandsIBA
01/2022 - 12/2004
13Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
01/2021 - 08/2003
12mouse dectin-2IBA
11/2023 - 05/2010
11Interleukin-12 (IL 12)IBA
10/2013 - 05/2002
10Interleukin-4 (Interleukin 4)IBA
01/2021 - 01/2002
10InterferonsIBA
11/2011 - 11/2001
9Dextrans (Dextran)FDA Link
01/2023 - 12/2008
9GlucansIBA
01/2023 - 06/2011
9AntibodiesIBA
11/2021 - 10/2004
9AutoantibodiesIBA
10/2017 - 03/2004
8sodium sulfate (sodium bisulfate)FDA LinkGeneric
01/2023 - 12/2008
8C-Type Lectins (C-Type Lectin)IBA
08/2022 - 02/2011
7Interleukin-22 (IL-22)IBA
01/2023 - 03/2008
7Monoclonal AntibodiesIBA
11/2021 - 04/2006
7Immunoglobulin G (IgG)IBA
01/2021 - 03/2002
7Anti-Bacterial Agents (Antibiotics)IBA
10/2019 - 03/2004
7Interleukin-1beta (Interleukin 1 beta)IBA
05/2009 - 03/2002
6OvalbuminIBA
05/2024 - 12/2002
6Interleukin-18 (Interleukin 18)IBA
11/2023 - 05/2002
6LipopolysaccharidesIBA
04/2023 - 11/2002
6HaptensIBA
11/2018 - 02/2005
6AllergensIBA
08/2014 - 02/2003
6Interleukin-1alpha (Interleukin 1 alpha)IBA
12/2008 - 11/2002
5Interleukin-17 ReceptorsIBA
12/2023 - 06/2009
5Pattern Recognition ReceptorsIBA
01/2022 - 02/2011
5CollagenIBA
01/2021 - 02/2004
5VaccinesIBA
01/2021 - 03/2002
5Toll-Like Receptors (Toll-Like Receptor)IBA
01/2020 - 01/2004
5Chemotactic FactorsIBA
11/2012 - 07/2004
4AzoxymethaneIBA
01/2023 - 02/2010
4Therapeutic UsesIBA
05/2022 - 05/2002
4MannansIBA
01/2022 - 05/2015
4Polysaccharides (Glycans)IBA
12/2021 - 08/2014
4LipidsIBA
01/2021 - 05/2002
4Tretinoin (Retinoic Acid)FDA LinkGeneric
01/2021 - 05/2007
4Imiquimod (Aldara)FDA LinkGeneric
10/2019 - 01/2017
4Angiotensin IIIBA
11/2018 - 02/2010
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2018 - 02/2004

Therapy/Procedure

18Therapeutics
01/2023 - 02/2008
7Transplantation
11/2022 - 08/2005
4Ligation
04/2023 - 02/2006